Better Pharma Processes LogoBetter Pharma Processes for Small Molecule Drugs
target compounds
Better Pharma Processes provides process chemistry consulting and training

Publications

Books and Reviews

Harrington, P.J.  “Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up”, John Wiley & Sons, Inc., Hoboken, 2011.

Abrecht, S.; Harrington, P.; Iding, H.; Karpf, M.; Trussardi, R.; Wirz, B.; Zutter, U.  “The Synthetic Development of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu®): A Challenge for Synthesis & Process Research”, Chimia  2004, 58, 621 [Chem. Abstr. 142:336053].

Harrington, P.J.; Lodewijk, E.L. “Twenty Years of Naproxen Technology”, Org. Proc. Res. Dev. 1997, 1, 72 [Chem. Abstr. 126:61806].
One of the top-ten most cited articles in Organic Process Research & Development, Vols. 1-10.

Harrington, P.J. ”Transition Metal Allyl Complexes: Trimethylenemethane Complexes”, Comprehensive Organometallic Chemistry II, Volume 12, Elsevier Science, Ltd., Oxford, UK, 1995.

Harrington, P.J.  “Transition Metal Allyl Complexes: Pd, W, Mo-Assisted Nucleophilic Attack”, Comprehensive Organometallic Chemistry II, Volume 12, Elsevier Science, Ltd., Oxford, UK, 1995.

Harrington, P.J.  “Transition Metals in Total Synthesis”, John Wiley & Sons, Inc., New York, 1990 [Chem. Abstr. 113:6587].

Research Publications

Harrington, P.J. “Atorvastatin Calcium: Structural Complexity to Synthetic Simplicity with Help from Nature”, Process Development and Scale-Up in the Pharmaceutical Industry Master Class at NUI Galway, Galway, Republic of Ireland, April 2012.

Harrington, P.J. “Bosentan: Is Process Improvement Possible after the Yield has been Optimized?”, Process Development and Scale-Up in the Pharmaceutical Industry Master Class at NUI Galway, Galway, Republic of Ireland, April 2012.

Harrington, P.J.  Streamlining Proess R & D: “Lessons Learned from Escitalopram”, 5th International Current Process Chemistry Conference, 02 June 2011, Philadelphia, PA.

Harrington, P.J.; Hildbrand, S.; Sarma, K.  “Process for the Preparation of 4’-Azido Cytidine Derivatives”, US7632940 (12/15/2009).

Harrington, P.J.; Paulsen V.G.; Tucker, C.E.  “Process for Preparing Pyrazole Functionalized Benzodiazepinones”, WO2009100996 (8/20/2009).

Harrington, P.J.; Paulsen V.G.; Tucker, C.E.  “Process for Preparing Pyrazole Functionalized Benzodiazepinones”, US20090203901 (8/13/2009).

Brown, J.D.; Dauer, R.; Harrington, P.J.; Johnston, D.A.; Khatri, H.N.; Rowe, G.K.; Topping, R.J.  “Process for S-Aryl Cysteine”, EP1236715 (10/15/2008). 

Harrington, P.J.; Hildbrand, S.; Sarma, K.  “Process for Preparation of 4’-Azido Cytidine Derivatives”, WO2008071571 (6/19/2008).

Harrington, P.J.; Johnston, D.A.; Hodges, L.M.  “Process for Preparation of Pyridine Derivatives of NK-1 Receptor Antagonist”, US7384939 (6/10/2008).

Harrington, P.J. “Compounds and Methods for Carbazole Synthesis”, WO2007077111 (7/12/2007) [Chem. Abstr. 147:166194].

Harrington, P. J; Khatri, H.N.  “Preparation of Cyclic, Ketalized Ketones by Favorskii Rearrangement and the Use Thereof for the Preparation of Glucokinase Activator 70”, WO2007048717 (5/3/2007) [Chem. Abstr. 146:482076].

Harrington, P.J.; Johnston, D.; Moorlag, H.; Wong, J-W.; Hodges, L.M.; Harris, L.; McEwen, G.K.; Smallwood, B.  “Research and Development of an Efficient Process for the Construction of the 2,4,5-Substituted Pyridines of NK-1 Receptor Antagonists”, Org. Proc. Res. Dev. 2006, 10, 1157[Chem. Abstr. 146:83545].

Harrington, P.J.; Hodges, L.M.; Johnston, D.A. “Process for Preparing Pyridinecarboxamide Derivatives used as Intermediates in the Synthesis of NK-1 Receptor Antagonists”, WO2006002860 (1/12/06) [Chem. Abstr. 144:128858].

Harrington, Peter J. “Construction of the Pyridine Core of NK-1 Receptor Antagonists”,
Gordon Research Conference on Organic Reactions and Processes, 2 August, 2005, 
Bryant University, Smithfield, RI.

Goehring, W.; Harrington, P.J.; Hodges, L.M.; Johnston, D.A.; Rimmler, G. “Process for Preparation of 4-Phenylpyridine-3-carboxamide Derivatives”, US2005014792 (1/20/05) [Chem. Abstr. 142:134474].

Brown, J.D.; Harrington, P.J.; Hughes, R.C.  “Process for Preparing 1,2-Diamino Compounds”, US7122684 (10/17/06) [Chem. Abstr. 141:277243].

Brown, J.D.; Khatri, H.N.; Harrington, P.J.; Johnston, D.A.; Topping, R.J.; Dauer, R.R.; Rowe, G.K. “Preparation for S-Aryl-Cysteine and Its Derivatives”, US6765109 (7/20/04).

Harrington, Peter J. “Construction of the Pyridine Core of NK-1 Receptor Antagonists”, 10th International Conference on Organic Process Research & Development, 15 July, 2004, Vancouver, BC.

Harrington, P.J.; Brown, J.D.; Foderaro, T.; Hughes, R.C.  “Research and Development of a Second-Generation Process for Oseltamivir Phosphate, Prodrug for a Neuraminidase Inhibitor”, Org. Proc. Res. Dev. 2004, 8, 86 [Chem. Abstr. 140:148071].
One of the most-accessed articles (#15) in Organic Process Research & Development, Vol. 8

Harrington, Peter J.  “Synthetic Strategy in Process Evaluation and Optimization,” 7th International Conference on Organic Process Research & Development, 17 March 2003, New Orleans, LA.

Harrington, P.J.; Khatri, H.N.; DeHoff, B.S.; Guinn, M.R.; Boehler, M.A.; Glaser, K.A.
“Research and Development of a Second Generation Process for Bosentan, an Endothelin Receptor Antagonist”, Org. Proc. Res. Dev. 2002, 6, 120 [Chem. Abstr. 136:279420].

Harrington, P.J.; Khatri, H.N.; Schloemer, G.C. “Preparation of Ketorolac”, US6323344 (11/27/01) [Chem. Abstr. 134:207709].

Harrington, P.J.; Hodges, L.M.; Puentener, K.; Scalone, M. “Synthesis of 3,6-Dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one”, US6552204 (4/22/03) [Chem. Abstr. 135:166783].

Brown, J.D.; Khatri, H.N.; Harrington, P.J.; Johnston, D.A.; Topping, R.J.; Dauer, R.R.; Rowe, G.K. “Preparation for S-Aryl-Cysteine and Its Derivatives”, US6229041 (5/8/01) [Chem. Abstr. 132:64525].

Harrington, P.J.; Khatri, H.N.; Schloemer, G.C. “Preparation of Ketorolac”, US6197976 (3/6/01) [Chem. Abstr. 134:207709].

Harrington, P.J.; Khatri, H.N.; DeHoff, B.S. “Preparation of Sulfonamides”, US6136971 (7/15/99) [Chem. Abstr. 133:309904].

Harrington, P.J. “Preparation of Mibefradil via an Acetamide Anion”, US5892055 (4/6/99).

Wong, J-w.; Harrington, P.J. “Preparation of Mibefradil via an Acetonitrile Anion”, US5811557 (9/22/98) [Chem. Abstr. 129:245150].

Harrington, P.J.; Wong, J-w. “Preparation of Mibefradil via a Naphthalenylacetic Acid”, US5811556 (9/22/98) [Chem. Abstr. 129:245149].

Harrington, P.J.; Fleming, M.P. “Preparation of Mibefradil via an Acetamide Anion”, US5808088 (9/15/98) [Chem. Abstr. 129:230726].

Harrington, P.J.  “Second Generation Process Design and Development for Posicor: How to Convert Simple Chemical Knowledge to Millions in Profit”, CU-Roche Colorado Synthetic Chemistry Symposium, 21 May 1998, Boulder, CO
.
Harrington, P.J.; Lodewijk, E.L. “Twenty Years of Naproxen Technology”, 13th SCI Process Development Symposium, 13 December 1995, Stevenage, Herts, UK.

Harrington, P.J.  J. Amer. Chem. Soc. 1995, 117, 1861 (book review) [Chem. Abstr. 1995:352158].

Schloemer, G.C.; Han, Y-K.; Harrington, P.J. “Preparation of Acyclovir Using 1,3-Dioxolane”, US5567816 (10/22/96) [Chem. Abstr. 126:19174].

Harrington, P.J., Sanchez, I.H.  “N-p-Toluenesulfonylpyrroles from 1,3-Dienes”, Syn. Comm. 1994, 24, 175 [Chem. Abstr. 120:191464].

Harrington, P.J.; Sanchez, I.H.  “Application of the Cyanurate-Isocyanurate Rearrangement to Amine Synthesis: Preparation of 2-(2-Thienyl)ethylamine”, Syn. Comm. 1993, 23, 1307 [Chem. Abstr. 119:160016].

Harrington, P.J.; Sanchez, I.H.  “Preparation of 2-(2-Thienyl)ethylamine and Thieno[3,2-c]-pyridine Derivatives”, EP522956 (1/13/93) [Chem. Abstr. 118:254911].

Beardsley, G.P.; Fletcher, S.R.; Harrington, P.J.; Taylor, E.C.  “Pyrido[2,3-d]pyrimidine Derivatives -Intermediates in Forming Anti-neoplastic Agents”, US5026852 (6/25/91).

Hegedus, L.S.; Sestrick, M.R.; Michaelson, E.T.; Harrington, P.J.  “Palladium Catalyzed Reactions in the Synthesis of 3- and 4-Substituted Indoles.4.”, J. Org. Chem. 1989, 54, 4141 [Chem. Abstr. 111:115652].

Beardsley, G.P.; Fletcher. S.R.; Harrington, P.J.; Taylor, E.C.  “New Glutamic Acid Compounds Useful as Antineoplastic Agents - N-(4-((2-Amino-4-substituted-pyrido[2,3- d]pyrimidinyl)alkyl)-benzoyl-L-glutamic Acid Derivatives”, US4845216 (7/4/89).

Hegedus, L.S.; Toro, J.L.; Miles, W.H.; Harrington, P.J.  “Palladium-Catalyzed Reactions in the Synthesis of 3- and 4-Substituted Indoles. III. Total Synthesis of (+)-Aurantioclavine”, J. Org. Chem. 1987, 52, 3391 [Chem. Abstr. 107:134536].

Harrington, P.J.; DiFiore, K.A.  “A Preparation of 3-Aryl-2,5-dihydrothiophene-1,1-dioxides from Aryl Iodides”, Tetrahedron Lett. 1987, 28, 495 [Chem. Abstr. 107:134147].

Harrington, P.J.; Hegedus, L.S.; McDaniel, K.F.  “Palladium-Catalyzed Reactions in the Synthesis of 3-and 4-Substituted Indoles. II. Total Synthesis of the N-Acetyl Methyl Ester of (+)-Clavicipitic Acids”, J. Amer. Chem. Soc. 1987, 109, 4335 [Chem. Abstr. 107:78139].

Taylor, E.C.; Wong, G.S.K.; Fletcher, S.R.; Harrington, P.J.; Beardsley, G.P.; Shih, C.J.  “Chem. Biol. Pteridines, 1986, Pteridines Folic Acid Deriv., Proc. Int. Symp. Pteridines Folic Acid Deriv.: Chem., Biol. Clinical Aspects, 8th, 1986 [Chem. Abstr. 107:176424].

Taylor, E.C.; Harrington, P.J.; Fletcher, S.R.; Beardsley, G.P.; Moran, R.G.  “Synthesis and Anti-leukemic Activity of 5,10-Dideazaaminopterin and 5,10-Dideaza-5,6,7,8-tetrahydroaminopterin”,  J. Med. Chem. 1985, 28, 914 [Chem. Abstr. 103:6676].

Hegedus, L.S.; Harrington, P.J.  “Palladium Catalysis in the Synthesis of Nitrogen Heterocycles”, ACS Meeting, Great Lakes and Central Regions, Kalamazoo, MI, 1984.

Harrington, P.J.; Hegedus, L.S.  “Palladium-Catalyzed Reactions in the Synthesis of  3- and 4-Substituted Indoles - Approaches to the Ergot Alkaloids”, J. Org. Chem. 1984, 49, 2657 [Chem. Abstr. 101:54853].

Hegedus, L.S.; Harrington, P.J.  “Organopalladium Routes to the 4-Substituted Indoles and Clavines”, 18th Annual ACS Midwest Regional Meeting, Lawrence, KS, 1983.

Beardsley, G.P.; Fletcher, S.R.; Harrington, P.J.; Taylor, E.C.  “New Tetrahydropyrido[2,3-d]pyrimidines - Useful as Antineoplastic Agents, in the Manner of  Methotrexate”, US4684653 (8/4/87).

Taylor, E.C.; Beardsley, G.P.; Harrington, P.J.; Fletcher, S.R. “N-[(Pyridopyrimidinylethyl)benzoyl]glutamic Acid Derivatives”, PCT Int. Appl. WO 86005181 (9/12/86) [Chem. Abstr. 106:33470].

Taylor, E.C.; Palmer, D.C.; George, T.G.; Fletcher, S.R.; Tseng, C.P.; Harrington, P.J.; Beardsley, G.P.  “Biological Activity of L-5-Deazafolic Acid and L-5-Deazaaminopterin: Synthetic Strategies to 5-Deazapteridines”, J. Org. Chem. 1983, 48, 4852 [Chem. Abstr. 101:55505 and 100:103829].

Taylor, E.C.; Tseng, C.P.; Harrington, P.J.; Beardsley, G.P.; Rosowsky, A.; Wick, M.  “Chem. Biol. Pteridines, Proc. Int. Symp. Pteridines Folic Acid Deriv.: Chem. Biol. Clin. Aspects, 7th, 1982 [Chem. Abstr. 100:68665].

Harrington, Peter John  “Synthetic Approaches to 5-Deaza- and 5,10-Dideazafolic Acid Analogs”, Diss. Abstr. Int. B  1982, 43, 138 [Chem. Abstr. 98:179838].

Taylor, E.C.; Palmer, D.C.; Fletcher, S.R.; Harrington, P.J.  “Deazaantifolates”, 8th International Congress of Heterocyclic Chemistry, Karl-Franzens Universitat, Graz, Austria, 1981.